Conclusive Evidence
The trouble with “conclusive evidence” is a causal sort of way is that it depends on first/early second order effects, or thereabouts.
Human endeavour by and large is unable to account for Nth order impact. I include scientific observations and theories and all our models of a complex world in this as well.
There’s always the risk of being wrong, and “mumbo jumbo”, but we do need a more — there you go — holistic or systems way of thinking of large scale and complex problems without getting boxed into the “conclusive” boxes. Our ability to learn and recreate models will be really slow and the reality changes a lot faster than that.
So let’s not get gated and wait on “knowing” everything.